Name
Jing Han, Department of Occupational and Environmental Health, School of Public Health, Xi'an Jiaotong University, Professor, Doctoral Supervisor. The EEOD team leader.
(Personal homepage: https://gr.xjtu.edu.cn/web/hanjing.hj)
Research Field (Direction)
Pathogenesis of bone and cartilage diseases with protein and glycoproteomics.
Preparation and biological evaluation of cartilage repair materials.
Identification of occupational harmful factors and health promotion of occupational population (mechanism and protection)
The relationship between environmental pollutants (BPA, PFAS, PAHs, heavy metal elements and PM2.5, etc.) and chronic diseases
Research on the healthy growth of adolescents (physical, psychological, learning ability, career planning, etc.)
Educational Background
2009.09-2013.10 School of Public Health, Xi'an Jiaotong University, Doctor of Medicine
2006.09-2009.07 Biomedical Engineering Research Center, Xiamen University, Master of Science
2001.09-2005.07 School of Pharmaceutical Sciences, Xi'an Jiaotong University, Bachelor of Science and Economics
Work Experience
2024.01-now Department of Occupational and Environmental Health, School of Public Health, Xi'an Jiaotong University, Professor
2020.11-2021.10 The High School Affiliated to Xi'an Jiaotong University (Yanta campus), Vice Principal (on secondment)
2019.04-2021.04 School of Public Health, Xi'an Jiaotong University, Department of Occupational and Environmental Health, Deputy Head (in charge)
2016.12-2023.12 Department of Occupational and Environmental Health, School of Public Health, Xi'an Jiaotong University, Associate Professor
2015.09-2016.09 Department of Biomaterials, School of Mechanical Engineering, National University of Singapore, Visiting Scholar
2013.11-2017.04 Department of Material Processing Engineering, School of Materials, Xi'an Jiaotong University, Postdoctoral Fellow
2013.11-2016.12 Department of Occupational and Environmental Health, School of Public Health, Xi'an Jiaotong University, Lecturer
2011.08-2011.11 School of Life Sciences, University of Eastern Finland, Visiting Scholar
2005.07-2006.09 Shaanxi University of Chinese Medicine, Teacher
Teaching and research results, patents, papers
Since 2013, I have presided over more than 30 research projects and received a total of over 10 million RMB. Up to now, I have published 134 academic papers, including 100 pieces of SCI papers (77 pieces of SCI papers were published as first author/only corresponding author) and 16 pieces of papers in Chinese core journals as first/corresponding author. Four invention patents and one utility‑model patent have been granted. I have been awarded the third prize of Science and Technology of Shaanxi Province (first completer), the second prize of the 2023 Invention and Entrepreneurship Award (first completer), the Person Award of the 13th Invention and Entrepreneurship Award of 2023, the second prize of science and technology of Shaanxi Province Higher Education Institution (first completer), the Science and Technology Award of Shaanxi Province for Environmental Protection (fourth completer), award for doctoral students and the 7th Edition of International Research Best Researcher Award. In 2026, I was selected for the National Health and Wellness Talent Capacity‑Building Program (Talent Program for Professionals Familiar with International Public Health Regulations). In 2023, I was selected into the first Public Health High-level Talent Training Program of Chinese Preventive Medical Association. Currently, I am the chief expert of the research team on health risks, effects, and prevention and control of exposure to novel environmental pollutants, and I serve as a provincial occupational health expert in Shaanxi Province, member of the 6th Council of Shaanxi Preventive Medicine Association. Standing Committee of the Occupational, Environmental and Occupational Disease Branch of Xi'an Medical Association, and Committee on the Promotion of Endemic Diseases in Health Promotion Association in Shaanxi Province, and Nutrition and Food Safety Professional Committee of Preventive Medicine Association in Shaanxi Province. I have participated in the compilation of Famine Starvation and Nutrient Deprivation From Biology to Policy and Fundamentals and Applications of Molecular Biology of Endemic Diseases (editorial member). Served as youth editorial board member of Hygiene and Environmental Health Advances and guest editor of Nutrients.
Major research projects
National Natural Science Foundation of China, General Program-Research on the Mechanisms Underlying the Health Effects of Environmental Low-Selenium Exposure on Articular Cartilage and Targeted Intervention Using Nano-Selenium; Funding of 490,000 Yuan; Funding Period: January 1, 2027-December 31, 2030; In charge
Shaanxi Provincial Natural Science Foundation Basic Research Program-Key Project-Youth Project (Category A; formerly the Outstanding Young Scholar Project), Project Number: 2026JC-JCQN-146; Research on the Role of Macrophage Polarization in Bisphenol A-Induced Synovial Joint Injury and the Effect of Injectable Hydrogel Intervention; Funding of 500,000 Yuan; Funding Period: January 1, 2026-December 31, 2029; In charge
Xi'an Municipal Natural Science Foundation Project-Key Project; Research on the Association and Mechanisms Between Heavy Metal Exposure and Metabolic Disorders Related to Obesity Among Oilfield Occupational Populations; Funding of 300,000 Yuan; In charge
National Natural Science Foundation of China, "The molecular mechanism of mTOR signal pathway and mitochondria-endoplasmic reticulum autophagy in chondrocyte damage with Kashin-Beck disease", Project number 81872567, Funding of 570,000 Yuan, From 2019/01/01 to 2022/12/31; Completed
The National Natural Science Foundation of China Youth Science Foundation Project, "The role of abnormal chondroitin sulfate biosynthesis and catabolism in the cartilage damage of Kashin-Beck Disease", Funding of 230,000 Yuan, Project number 81402639, From 2015/01/01 to 2017‑12‑31, Completed
Project of Shaanxi Provincial Academy of Environmental Sciences, "China's Capacity Building Project for the Implementation of the Minamata Convention on Mercury (three bids)", Project number 202012257, Funding of 978,000 Yuan, From 2021/01/01 to 2021‑12‑31; Completed
Project of South China Institute of Environmental Sciences, Ministry of Ecology and Environment, "Environment and Health Risk Sentinel Monitoring of an Industrial Park in Shaanxi-Population Health Monitoring", Project number 21111011101EHSM-SXSM-02, Total funding of 380,000 Yuan, From 2019/06/14 to 2020/12/31; Completed
Representative Papers (* Corresponding author)
Han Jing#,*, Deng Huan#, Li Yang#, Qiao Lichun, Jia Hongrui, Zhang Lan, Wang Linghang, Qu Chengjuan. Nano-elemental selenium particle developed via supramolecular self-assembly of chondroitin sulfate A and Na2SeO3 to repair cartilage lesions. Carbohydrate Polymers, 2023, 316:121047.
Lin Xue#, Liu Haobiao#, Qiao Lichun#, Deng Huan, Bao Miaoye, Yang Zhihao, He Yujie, Xiang Rongqi, He Huifang, Han Jing*. Chondrocyte autophagy mediated by T-2 toxin via AKT/TSC/Rheb/mTOR signaling pathway and protective effect of CSA-SeNP. Osteoarthritis and Cartilage. 2024, 32(10):1283-1294.
Lyu Yizhen#, Deng Huan#, Qu Chengjuan#, Qiao Lichun, Liu Xuan, Xiao Xiang, Liu Jiaxin, Guo Ziwei, Zhao Yan, Han Jing*, Lammi Mikko J. Identification of proteins and N-glycosylation sites of knee cartilage in Kashin-Beck Disease compared with osteoarthritis. International Journal of Biological Macromolecules. 2022, 210:128-138.
Deng Huan, Lin Jinyan, Jiang Yude, Amhare Abebe Feyissa, Qiao Lichun, Wang Jun*, Han Jing*. Chondroitin sulfate A-selenium nanoparticles protect chondrocytes from T-2 toxin-induced oxidative stress and mitochondrial dysfunction through activating autophagy by the SIRT1-AMPK-FOXO3 pathway. Ecotoxicology and Environmental Safety. 2025;303:118797.
Deng Huan, Lin Xue, Xiang Rongqi, Bao Miaoye, Qiao Lichun, Liu Haobiao, He Huifang, Wen Xinyue, Han Jing*. Low selenium and T-2 toxin may be involved in the pathogenesis of Kashin-Beck disease by affecting AMPK/mTOR/ULK1 pathway mediated autophagy. Ecotoxicology and Environmental Safety. 2024, 279:116503.
Deng Huan, Deng Feidan, Wen Xinyue, Jiang Yude, Amhare Abebe Feyissa, Qiao Lichun, Li Miaoqian, Wan Ping, Wang Jun*, Han Jing*. Targets and potential mechanism of chondroitin sulfate A-selenium nanoparticle on Kashin-Beck disease chondrocytes. Biological Trace Element Research. 2025.
Han Jing, Li Danyang, Qu Chenjuan, Wang Dong, Wang Liyun, Guo Xiong, Lammi Mikko J. Altered expression of chondroitin sulfate structure modifying sulfotransferases in the articular cartilage from adult osteoarthritis and Kashin-Beck disease. Osteoarthritis and Cartilage. 2017, 25(8):1372-1375.
Han Jing#*, Deng Huan#, Lyu Yizhen, Xiao Xiang, Zhao Yan, Liu Jiaxin, Guo Ziwei, Liu Xuan, Qiao Lichun, Lammi Mikko Juhani*. Identification of N-Glycoproteins of knee cartilage from adult osteoarthritis and Kashin-Beck disease based on quantitative glycoproteomics, compared with normal control cartilage. Cells. 2022,11(16):2513.
Qiao Lichun#, Guo Ziwei#, Liu Haobiao#, Liu Jiaxin, Lin Xue, Deng Huan, Liu Xuan, Zhao Yan, Xiao Xiang, Lei Jian, Han Jing*. Protective effect of mitophagy regulated by mTOR signaling pathway in liver fibrosis associated with selenium. Nutrients. 2022,14(12):2410.
Qiao Lichun#, Lin Xue#, Liu Haobiao#, Xiang Rongqi, Zhan Jingming, Deng Feidan, Bao Miaoye, He Huifang, Wen Xinyue, Deng Huan, Wang Xining, He Yujie, Yang Zhihao, Han Jing*. T-2 toxin induces cardiac fibrosis by causing metabolic disorders and up-regulating Sirt3/FoxO3α/MnSOD signaling pathway-mediated oxidative stress. Journal of Environmental Sciences. 2025, 150:532-544.
Qiao Lichun#, Shi Shaoteng#, Wang Liangjia#, Muhammad Aftab Shafiq, Tang Jing, Li Miaoqian, Wan Ping, Zhou Jingxuan, Dai Xulei, Han Jing*, Guo Yijie.* Multi-dimensional analysis revealing the mechanism of T-2 toxin driving liver fibrosis: integration of network toxicology, machine learning, experimental verification, and molecular docking. Chemico-Biological Interactions. 2026, 435:112155.
Qiao Lichun#, Liu Xuan#, He Yujie#, Zhang Jiaheng, Huang Hao, Bian Wenming, Chilufya Mumba Mulutula, Zhao Yan, Han Jing*. Progress of signaling pathways, stress pathways, and epigenetics in the pathogenesis of skeletal fluorosis. International Journal of Molecular Sciences. 2021, 21(22): 11932.
Qiao Lichun, Li Miaoqian, Deng Feidan, Wen Xinyue, Deng Huan, Xue Zhaowei, Zhou Jingxuan, Lin Jinyan, Amhare Abebe Feyissa, Xiang Rongqi, Fan Xiangyu, Wang Jun*, Han Jing*. Epidemiological trends of osteoarthritis at the global, regional, and national levels from 1990 to 2021 and projections to 2050. Arthritis Research & Therapy. 2025;27(1):199.
Liu Haobiao#, Lin Xue#, Chilufya Mumba Mulutula#, Qiao Lichun, Bao Miaoye, Wen Xinyue, Xiang Rongqi, He Huifang, Li Miaoqian, Han Jing*. Synergistic effects of T-2 toxin and selenium deficiency exacerbate renal fibrosis through modulation of the ERα/PI3K/Akt signaling pathway. Ecotoxicology and Environmental Safety. 2024, 269:115748.
Liu Haobiao, Jing Tang, Yingjie Cai, Licheng Yang, Qingsong Li, Xuefeng Yu, Husna Wali, Abebe Feyissa Amhare, Zhiyong Du, Ziwei Guo, Jing Han#, Tao Zhu#. Lipoprotein combined index and prevalent hyperuricemia among normolipidemic oilfield workers: a cross-sectional study. Frontiers in Endocrinology. 2026,17,1768222.
Liu Haobiao, Zhang Tianxiao, Jia Lianxu, Yang Bowei, Zhang Dianchao#, Han Jing#. Sex-Specific Effects of Tea Consumption and Salt Intake on Metabolic Syndrome and Its Components among Oilfield Workers. Frontiers in Nutrition. 2025;12:1614417.
Qingsong Li, Liu Haobiao, Xuefeng Yu, Jing Tang, Licheng Yang, Yingjie Cai, Zhihao Yang, Lianxu Jia#, Ziwei Guo#, Jing Han#. Association between blood lipid levels, BMI, and hypertension among employees in petrochemical enterprises. Frontiers in Cardiovascular Medicine. 2026,13, 1788552.
Xiao Xiang, Deng Huan, Lin Xue, Ali Ahmed Sameir Mohamed, Viscardi Angelo, Guo Ziwei, Qiao Lichun, He Yujie, Han Jing*. Selenium nanoparticles: Properties, preparation methods, and therapeutic applications. Chemico-Biological Interactions. 2023, 378:110483.
Ding Tiexin, Liu Fuwei, Xin He, Chen Yicheng, Kong Liang, Han Jing, Ma Dayan, Han Yong, Zhang Lan. Pyro-piezoelectric effect of BaTiO3 bio-nanocarrier for osteomyelitis therapy. Nano Today. 2024, 102069.
Ding Tiexin, Zhang Lan*, Han Jing, Zhou Jianhong, Han Yong*. Photo-Responded Antibacterial Therapy of Reinfection in Percutaneous Implants by Nanostructured Bio-Heterojunction. Small. 2023, 19(7), e2206265.
Contact information
E-mail: bbbishop@126.com
Contact number: 029-82655106
Contact Address: School of Public Health, Health Science Center, Xi'an Jiaotong University;
Global Health Research Institute, Building 21, Innovation Harbor.
