Wu Cuiyan
Cell-phone: (+86) 029-82655229
E-mail: wucuiyan@xjtu.edu.cn
Address: No. 76 Yanta West Road, Xi'an, Shaanxi, P.R. China. 710061
EDUCATION&TRAINING
Postdoctoraltraining, Xi’an Jiaotong University, Pharmacology, 2015-
Ph.D., Xi’an Jiaotong University, Epidemiology and Statistics, 2015
Master, Xi’an Jiaotong University, Epidemiology and Statistics, 2011
Bachelor, Jining Medicine College, Medical Laboratory Science, 2009
PROFESSIONAL EXPERIENCE, POSTIONS & EMPLOYMENT
Jul. 2018- Associate professor, School of Public Health,Xi’an Jiaotong University
Apr. 2015- Lecturer,School of Public Health,Xi’an Jiaotong University
GRANTS/RESEARCH SUPPORT
As Principal Investigator in charge
1.National Natural Science Fund of China,Jan.2016-Dec.2018,¥180,000 (about $27,000),Effects of PI3K/Akt signaling pathway on the regulation of autophagy and metabolism in chondrocytes with Kashin-Beck disease.
2.Financial Grant from the China Postdoctoral Science Foundation(Special Grant), Jul.2018/7-Jun.2020, ¥150,000 (about $22,000), Screening and function of key lncRNA during the differentiation from Kashin-Beck disease-induced pluripotent stem cells to chondrocytes.
3.Financial Grant from the China Postdoctoral Science Foundation(General Grant), Jul.2016-Jun.2018, ¥50,000 (about $7,600), LncRNA participates the pathogenesis of Kashin-Beck disease as a gene regulation mechanism.
4.Fundamental Research Funds for the Central Universities, Jan.2016-Dec.2018, ¥120,000 (about $18,000),The comparison oflncRNAexpressionprofileinosteoarthritischondrocytesandKashin-Beck diseasechondrocytes.
5.University Startup Support for Research,Apr.2015-Mar.2017,¥100,000 (about $15,000),The mechanisms of T-2 toxin induced chondrocytes function damage through PI3K/Akt-HIF-1α signaling pathway.
6.The Fund from Shaanxi Health and Family Planning Committee. Jan.2017-Dec.2018,¥20,000 (about $3,000),Thegene regulation mechanism of T-2 toxin inducingKashin-Beck disease.
HONORS & AWARDS
Science and Technology Award of Shaanxi Province (Second Prize), 2017, as thirdprincipalcompleter
Science and Technology AwardforInstitutionsof Shaanxi Province(First Prize),2016, assecondprincipalcompleter
PUBLICATIONS
1.Wu C, Liu H, Zhang F, Shao W, Yang , Ning Y, Wang S, Zhao G, Lee BJ, Lammi M, Guo X. Long noncoding RNA expression profile reveals lncRNAs signature associated with extracellular matrix degradation in kashin-beck disease. Scientific Reports. 2017, 7(1):17553.
2.Wu C, Wen Y, Guo X, Yang T, Shen H, Chen X, Tian Q, Tan L, Deng H-W, Zhang F. Genetic association, mRNA and protein expression analysis identify ATG4C as a susceptibility gene for Kashin-Beck disease. Osteoarthritis and cartilage. 2017, 25(2):281-286.
3.Wu C,Zheng J, Yao X, Shan H, Li Y, Xu P, Guo X. Defective autophagy in chondrocytes with Kashin-Beck disease but higher than osteoarthritis. Osteoarthritis and Cartilage, 2014, 22(11): 1936-1946.
4.Wu C,Lei R, Tiainen M, Wu S, Zhang Q, Pei F, Guo X. Disordered glycometabolism involved in pathogenesis of Kashin-Beck disease, an endemic osteoarthritis in China. Experimental Cell Research, 2014, 326(2): 240-250
5.Liang X#,Wu C#（Co-first author）, Zhao H, Liu L, Du Y, Li P, Wen Y, Zhao Y, Ding M, Cheng B, Cheng S, Ma M, Zhang L, Guo X, Shen H, Tian Q, Zhang F, Deng HW. Assessing the genetic correlations between early growth parameters and bone mineral density: A polygenic risk score analysis. Bone. 2018, 116:301-306.
6.Fan Q, Zhang F, Wang W, Xu J, Hao J, He A, Wen Y, Li P, Liang X, Du Y, Liu L,Wu C, Wang S, Wang X, Ning Y, Guo X.GWAS summary-based pathway analysis correcting for the genetic confounding impact of environmental exposures. Briefings in Bioinformatics. 2018, 19(5):725-730.
7.Yang L, Zhang J, Zhao G,Wu C, Ning Y, Wang X, Lammi MJ, Guo X. Gene expression profiles and molecular mechanism of cultured human chondrocytes' exposure to T-2 toxin and deoxynivalenol. Toxicon. 2017, 140:38-44.
8.Fan Q, Wang W, Hao J, He A, Wen Y, Guo X,Wu C, Ning Y, Wang X, Wang S, Zhang F. Integrating genome-wide association study and expression quantitative trait loci data identifies multiple genes and gene set associated with neuroticism. Progress in Neuro-psychopharmacology & biological psychiatry. 2017, 78:149-152.
9.Wang W, Hao J, Zheng S, Fan Q, He A, Wen Y, Guo X,Wu C, Wang S, Yang T, Shen H, Chen X, Tian Q, Tan L, Deng HW, Zhang F. Tissue-specific pathway association analysis using genome-wide association study summaries. Bioinformatics. 2017, 33(2):243-247,
10.Hao J, Wang W, Wen Y, Xiao X, He A,Wu C, Wang S, Guo X, Zhang F. Genome-wide association study identifies COL2A1 locus involved in the hand development failure of Kashin-Beck disease. Scientific Reports. 2017, 7:40020.
11.Wang X, Ning Y, Yang L, Liu H,Wu C, Wang S, Guo X. Diagnostic value of circulating microRNAs for osteosarcoma in Asian populations: a meta-analysis. Clinical and Experimental Medicine. 2017,17(2):175-183.
12.Wen Y, Guo X, Hao J, Xiao X, Wang W,Wu C, Wang S, Yang T, Shen H, Chen X, Tan L, Tian Q, Deng HW, Zhang F. Integrative analysis of genome-wide association studies and gene expression profiles identified candidate genes for osteoporosis in Kashin-Beck disease patients. Osteoporosis International. 2016, 27(3): 1041-1046.
13.Wang S, Duan C, Liu H, Shao W,Wu C, Han J, Guo X. The roles of selenium, insulin-like growth factor binding protein 2 and suppressor of cytokine signaling 3 in the pathogenesis of Kashin-Beck disease. Biomarkers. 2016, 21(5):409-415.
14.Wang X, Ning Y, Zhang F, Yu F, Tan W, Lei Y,Wu C, Zheng J, Wang S, Yu H, Li Z, Lammi MJ, Guo X. Gene expression signature in endemic osteoarthritis by microarray analysis. International Journal of Molecular Sciences. 2015,16(5):1465-1481.
15.Wen Y, Hao J, Guo X, Xiao X,Wu C, Wang S, Yang T, Shen H, Chen X, Tan L, Tian Q, Deng HW, Zhang F. SWGDT: A sliding window-based genotype dependence testing tool for genome-wide susceptibility gene scan. Journal of biomedical informatics. 2015, 57: 38-41.
16.Liu J, Wang L, Guo X, Pang Q, Wu S,Wu C, Xu P, Bai Y. The role of mitochondria in T-2 toxin-induced human chondrocytes apoptosis. PLoS One, 2014, 9(9):e108394.
17.Wu S, Wang W, Zhang F,Wu C, Dennis B, Qu C, Bai Y, Guo X. Expression profiles of genes involved in apoptosis and selenium metabolism in articular cartilage of patients with Kashin-Beck osteoarthritis. Gene, 2014, 535(2): 124-130.
18.He S, Tan W, Wang S,Wu C, Wang P, Wang B, Su X, Zhao J, Guo X, Xiang Y. Genome-wide study reveals an important role of spontaneous autoimmunity, cardiomyocyte differentiation defect and antiangiogenic activities in gender-specific gene expression in Keshan disease. Chinese Medical Journal, 2014, 127(1): 72-78.
19.Zheng J,Wu C, Ma W, Zhang Y, Hou T, Xu H, Wu S, Yao X, Guo X. Abnormal expression of chondroitin sulphate N-acetylgalactosaminyltransferase 1 and Hapln-1 in cartilage with Kashin–Beck disease and primary osteoarthritis. International Orthopaedics, 2013, 37(10): 2051-2059.
20.Zheng J, Hou T, Gao L,Wu C, Wang P, Wen Y, Guo X. Association between CD14 gene polymorphism and periodontitis: a Meta-analysis. Critical Reviews in Eukaryotic Gene Expression, 2013, 23(2): 115-123.
21.Zheng J, Gao L, Hou T, Liu Z,Wu C, Wu S, Wang P, Wen Y, Yao X, Guo X. Association between TLR4 polymorphism and periodontitis susceptibility: a Meta-analysis. Critical Reviews in Eukaryotic Gene Expression, 2013, 23(3): 257-264.
22.Hou T, Gao L, Zheng J, Liu Z,Wu C, Liu Q, Wu S, Guo X. Matrix metalloproteinase-1 gene polymorphisms and periodontitis susceptibility: a meta-analysis based on 11 case-control studies. Gene, 2013, 521(1): 111-115.
23.Han J, Guo X, Lei Y, Dennis BS, Wu S,Wu C. Synthesis and characterization of selenium-chondroitin sulfate nanoparticles. Carbohydrate Polymers, 2012, 90(1): 122-126.
