文嫣 西安交通大学医学部 公共卫生学院 地方病研究所，副教授/博士生导师
研究领域（方向）：
1 大骨节病病因、发病机制及防治，大骨节病软骨损伤的表观遗传学调控机制
2 环境有害因素致骨软骨疾病的分子标志物及发病机制
3 基于基因组大数据挖掘的复杂性疾病发病机制研究
教授课程：
1 《Epidemiological methods on the environment - gene interaction》 研究生（留学生）课程 主讲
2 《Preventive Medicine》 本科生（留学生）课程
3 《环境－基因相互作用研究的流行病学方法》 研究生课程
4 《骨软骨分子生物学》 研究生课程
5 《医学遗传学》 研究生课程
个人教育及工作简历：
2011-2016, 西安交通大学公共卫生学院地方病研究所，博士研究生
2016-2020，西安交通大学公共卫生学院地方病研究所，讲师
2021-2022，英国利物浦大学肌肉骨骼健康与衰老性疾病研究中心，访问学者
2021-至今，西安交通大学公共卫生学院地方病研究所，副教授
学术兼职：
Nutrients(IF=5.9)客座编辑（主持特刊："Nutritional Supplements for Bone Health"， https://www.mdpi.com/journal/nutrients/special_issues/113K11L689）
陕西省保健学会地方病专业委员会 委员
团队简介：
倡导团结、友好、奋进的团队氛围，提倡踏实、耐心、坚韧的工作精神，尊重每一位年轻学子的发展意愿，鼓励每一位成员表达自己的科研想法。希望你在团队的打磨中，成为更好的自己！
基金主持、论文发表、科研获奖、专利申请等科研成果：
共主持国家级/省部级、校级科研项目4项，包含国家自然科学基金青年项目、面上项目各1项，作为主要参与人参与国家重点研发计划“常见多发病防治研究”重点专项1项（负责“大骨节病软骨损伤的表观调控机制”部分研究内容）。累计发表论文42篇，其中SCI收录论文40篇，中文核心期刊论文2篇，包含第一作者/共同第一作者论文11篇，通讯/共同通讯作者7篇，最高影响因子9.3。文章发表在多个骨软骨疾病研究领域或生物信息学研究领域国际知名期刊，例如Arthritis & Rumatology、Bone、Bone & Joint Research、Osteoarthritis and Cartilage、Calcified Tissue International、Cartilage、Arthritis Research & Therapy、 Osteoporosis International、Bioinformatics、Schizophrenia Bulletin、Journal of Biomedical Informatics等。并为Nutrients、Cartilage、Progress in Neuro-Psychopharmacology and Biological Psychiatry等国际期刊担任同行评审专家。获得专利一项，作为主要参与人完成的“高通量组学分析方法开发及其在骨病研究中的应用”项目曾获2018年“陕西省科学技术奖二等奖”，并参编书籍《地方病分子生物学基础与应用》、《环境与基因相互作用的流行病学方法》等。发表的部分文章如下：
[1] Yifan Gou#, Jingxi Zhang#, Chun’e Li, Ye Liu, Jingni Hui, Ruixue Zhou, Meijuan Kang, Chen Liu, Bingyi Wang, Panxing Shi, Yan Wen*, Feng Zhang. Causal Relationship between Gut Microbiota and Rheumatoid Arthritis: A Two-Sample Mendelian Randomization Study. Clinical and experimental rheumatology. 2023 accepted
[2] Jingni Hui#, Yujing Chen#, Chun’e Li, Yifan Gou, Ye Liu, Ruixue Zhou, Meijuan Kang, Chen Liu, Bingyi Wang, Panxing Shi, Shiqiang Cheng, Xuena Yang, Chuyu Pan, Yumeng Jia, Bolun Cheng1, Huan Liu1, Yan Wen*, Feng Zhang*. Insight into the causal relationship between gut microbiota and back pain: A two Sample Bidirectional Mendelian Randomization Study. Advanced genetics. 2023 accepted
[3] Xuena Yang#, Xue Xiao#, Lu Zhang, Bo Wang, Ping Li, Bolun Cheng, Chujun Liang, Mei Ma, Xiong Guo, Feng Zhang, Yan Wen*. An integrative analysis of DNA methylation and transcriptome showed the dysfunction of MAPK pathway was involved in the damage of human chondrocyte induced by T-2 toxin. BMC Molecular and Cell Biology. 2022;23(1):4.
[4] Bolun Cheng#, Chujun Liang#, Xuena Yang, Ping Li, Li Liu, Shiqiang Cheng, Yumeng Jia, Lu Zhang, Mei Ma, Xin Qi, Yao Yao, Xiaomeng Chu, Jing Ye, Chao Lu, Xiong Guo, Yan Wen*, Feng Zhang*. Genetic association scan of 32 osteoarthritis susceptibility genes identified TP63 associated with an endemic osteoarthritis, Kashin-Beck disease. Bone. 2021;150:115997.
[5] Mei Ma#, Xiao Liang#, Xi Wang, Lu Zhang, Shiqiang Cheng, Xiong Guo, Feng Zhang, Yan Wen*. The molecular mechanism study of COMP involved in the articular cartilage damage of Kashin-Beck disease. Bone & Joint Research. 2020;9(9):578-586.
[6] Yan Wen, Ping Li, Jingcan Hao, Chen Duan, Jing Han, Awen He, Yanan Du, Li Liu, Xiao Liang, Feng Zhang*, Xiong Guo*. Integrating genome-wide DNA methylation and mRNA expression profiles identified different molecular features between Kashin-Beck disease and primary osteoarthritis. Arthritis Research & Therapy. 2018;20(1):41.
[7] C. Wu#, Y. Wen#, X. Guo, T. Yang, H. Shen, X. Chen, Q. Tian, L. Tan, H.-W. Deng, F. Zhang*. Genetic association, mRNA and protein expression analysis identify ATG4C as a susceptibility gene for Kashin-Beck disease.Osteoarthritis and Cartilage. 2017;25(2):281-286.
[8] Y. Wen, X. Guo, J. Hao, X. Xiao, W. Wang, C. Wu, S. Wang, T. Yang, H. Shen, X. Chen, L. Tan, Q. Tian, H.-W. Deng, F. Zhang*. Integrative analysis of genome-wide association studies and gene expression profiles identified candidate genes for osteoporosis in Kashin-Beck disease patients. Osteoporosis International. 2016;27(3):1041-1046.
[9] Yan Wen, Jingcan Hao, Xiao Xiao, Wenyu Wang, Xiong Guo, Weimin Lin, Tielin Yang, Xiaogang Liu, Hui Shen, Lijun Tan, Xiangding Chen, Qing Tian, Hong-Wen Deng, Feng Zhang*. PPARGC1B gene is associated with Kashin-Beck disease in Han Chinese. Functional & Integrative Genomics. 2016;16(4):459-463.
[10] Y Wen, J Hao, X Xiao, X Guo, W Wang, T Yang, H Shen, Q Tian, L Tan, H-W Deng, F Zhang*. Evaluation of the relationship and genetic overlap between Kashin-Beck disease and body mass index. Scandinavian Journal of Rheumatology. 2016;45(6):512-517.
[11] Yan Wen, Wenyu Wang, Xiong Guo, Feng Zhang*. PAPA: a flexible tool for identifying pleiotropic pathways using genome-wide association study summaries. Bioinformatics. 2016;32(6):946-948. (IF=7.307)
[12] Feng Zhang, Yan Wen, Xiong Guo*, Yingang Zhang, Xi Wang, Tielin Yang, Hui Shen, Xiangding Chen, Qing Tian, Hong-Wen Deng. Genome-wide association study identifies ITPR2 as a susceptibility gene for Kashin-Beck disease in Han Chinese. Arthritis & Rheumatology. 2015;67(1):176-181. (IF=10.995)
[13] Yan Wen#, Jingcan Hao#, Xiong Guo, Xiao Xiao, Cuiyan Wu, Sen Wang, Tielin Yang, Hui Shen, Xiangding Chen, Lijun Tan, Qing Tian, Hong-Wen Deng, Feng Zhang*. SWGDT: A sliding window-based genotype dependence testing tool for genome-wide susceptibility gene scan. Journal of Biomedical Informatics. 2015;57:38-41.
[14] Yan Wen, Feng Zhang, Chunyan Li, Shulan He, Wuhong Tan, Yanxia Lei, Qiang Zhang, Hanjie Yu, Jingjing Zheng, Xiong Guo*. Gene expression analysis suggests bone development-related genes GDF5 and DIO2 are involved in the development of Kashin-Beck disease in children rather than adults. PLoS One. 2014;9(7):e103618.
[15] Feng Zhang#, Yan Wen#, Xiong Guo*, Tielin Yang, Hui Shen, Xiangding Chen, Lijun Tan, Qing Tian, Hong-Wen Deng. Trans-omics pathway analysis suggests that eQTLs contribute to chondrocyte apoptosis of Kashin-Beck disease through regulating apoptosis pathway expression. Gene. 2014;553(2):166-169.
[16] Feng Zhang, Yan Wen, Xiong Guo*, Yingang Zhang, Sen Wang, Tielin Yang, Hui Shen, Xiangding Chen, Lijun Tan, Qing Tian, Hong-Wen Deng. Genome-wide pathway-based association study implicates complement system in the development of Kashin-Beck disease in Han Chinese. Bone. 2015;71:36-41.
[17] Bolun Cheng, Yan Wen, Xuena Yang, Shiqiang Cheng, Li Liu, Xiaomeng Chu, Jing Ye, Chujun Liang, Yao Yao, Yumeng Jia, Feng Zhang*. Gut microbiota is associated with bone mineral density : an observational and genome-wide environmental interaction analysis in the UK Biobank cohort Bone & Joint Research. 2021;10(11):734-741.
[18] Yanan Du#, Ping Li#, Yan Wen#*, Xiao Liang, Li Liu, Bolun Cheng, Miao Ding, Yan Zhao, Mei Ma, Lu Zhang, Shiqiang Cheng, Xiong Guo, Feng Zhang*. Evaluating the Correlations Between Osteoporosis and Lifestyle-Related Factors Using Transcriptome-Wide Association Study. Calcified Tissue International. 2020;106(3):256-263.
[19] Shiqiang Cheng, Xin Qi, Mei Ma, Lu Zhang, Bolun Cheng, Chujun Liang, Li Liu, Ping Li, Om Prakash Kafle, Yan Wen*, Feng Zhang*. Assessing the Relationship Between Gut Microbiota and Bone Mineral Density. Frontiers in genetics. 2020;11:6.
[20] Li Liu#, Yan Wen#, Yujie Ning#, Ping Li, Bolun Cheng, Shiqiang Cheng, Lu Zhang, Mei Ma, Xin Qi , Chujun Liang, Tielin Yang, Xiangding Chen, Lijun Tan, Hui Shen, Qing Tian, Hong-Wen Deng, Xiancang Ma, Feng Zhang*, Feng Zhu*. A trans-ethnic two-stage polygenetic scoring analysis detects genetic correlation between osteoporosis and schizophrenia. Clinical and Translational Medicine. 2020;9(1):21. (IF=7.919)
[21] Li Liu#, Yan Wen#, Lei Zhang, Peng Xu, Xiao Liang, Yanan Du, Ping Li, Awen He, Qianrui Fan, Jjingcan Hao, Wenyu Wang, Xiong Guo, Hui Shen, Qing Tian, Feng Zhang*, Hong-Wen Deng*. Assessing the associations of blood metabolites with osteoporosis: a Mendelian randomization study. The Journal of Clinical Endocrinology and Metabolism. 2018;103(5):1850-1855. (IF=5.789)
[22] W. Wang#, Y. Yu#*, J. Hao#, Y. Wen , J. Han, W. Hou, R. Liu, B. Zhao, A. He , P. Li , Q. Fan , C. Wu , S. Wang , X. Wang , Y. Ning, X. Guo , F. Zhang*. Genome-wide DNA methylation profiling of articular cartilage reveals significant epigenetic alterations in Kashin-Beck disease and osteoarthritis. Osteoarthritis Cartilage. 2017;25(12):2127-2133.
[23] X Xiao, J Hao, Y Wen, W Wang, X Guo, F Zhang*. Genome-wide association studies and gene expression profiles of rheumatoid arthritis: An analysis. Bone & Joint Research. 2016;5(7):314-319.
[24] Feng Zhang, Yan Wen, Xiong Guo*. CRISPR/Cas9 for genome editing: progress, implications and challenges. Human Molecular Genetics. 2014;23(R1):R40-6. (IF=6.393)
[25] Yan Wen, Ping Li, Weizhuo Wang, Chen Duan, Xiong Guo, Feng Zhang*. Integrative analysis of global DNA methylation and mRNA expression profile data in Kashin-beck Disease. The American Society of Human Gentics 2017 Annual Meeting. Orlando, Florida, USA. 2017/10/17-2017/10/21（会议论文）
联系方式：
电子邮箱：wenyan@xjtu.edu.cn
联系地址：西安交通大学医学部行政楼四楼
