王溪 西安交通大学医学部 公共卫生学院 副教授/博导
联系方式：地址: 西安市雁塔西路76号，西安交通大学医学部公共卫生学院 E-mail: wn18andlife@xjtu.edu.cn
工作经历：
2020年10月至今：西安交通大学医学院公共卫生学院 副教授
2019年8月-2020年8月：英国利物浦大学 助理研究员
2016年10月-2020年10月：西安交通大学公共卫生学院 讲师
课题组简介：
课题组每位成员都有各自擅长的领域，独特的想法和个性。团结是我们的特色，积极是我们的态度，努力是我们为实现目标与理想的唯一途径。“人类的一切智慧是包含在这四个字里面的：‘等待’和‘希望’！”期待每一位积极、勇敢，不畏惧困难，对学习和生活充满激情与美好向往的同学加入我们。
研究方向：
1. 膳食营养与肠道菌群在环境与基因相关疾病发病机制中的作用；
2. 微量元素在生物地球化学性疾病发生中的作用机制；
3. 环境与基因相关疾病临床诊断、病因发病机制与防治研究；
4. 环境与基因相关疾病病因发病机制研究；
5. 生物地球化学性疾病动物模型建立与应用。
主持及参与基金：
主持国家自然科学基金面上项目、青年项目2项，中国博士后科学基金面上项目2项，陕西省自然科学基金青年项目1项，陕西省博士后基金1项，陕西省卫生健康项目和校内基本科研业务费及横向课题，共计8项，作为项目骨干参与1项国家重点研发计划“常见多发病防治研究”重点专项、1项中国科学技术部政府间科技合作-中韩合作项目。
科研成果：
发表SCI论文64篇，其中第一（共同一作）/通讯作者SCI论文30篇，单篇最高IF=13.352，第一/通讯作者SCI累计IF =140.18，发表在Environmental International、Arthritis Research & Therapy、 Cell Death & Disease、Experimental Cell Research、Scandinavian Journal of Rheumatology等本领域权威期刊上。获2017年陕西省科学技术奖二等奖。陕西省保健协会地方病专业委员会常务委员兼副秘书长。参加国际、国内学术会议5次，其中在2017年中华预防医学会全球卫生分会学术年会进行分会场报告，获得2016年中韩国际硒元素研讨会优秀大会报告一次。参与编写中英文论著4部，其中副主编1部。
代表性论文（*通讯作者）：
1. Wang X, Ning Y, Li C, Gong Y, Huang R, Hu M, Poulet B, Xu K, Zhao G, Zhou R, Lammi MJ, Guo X. Alterations in the gut microbiota and metabolite profiles of patients with Kashin-Beck disease, an endemic osteoarthritis in China. Cell Death Dis. 2021 Oct 28;12(11):1015.
2. Wang X, Ning Y, Zhang P, Poulet B, Huang R, Gong Y, Hu M, Li C, Zhou R, Lammi MJ, Guo X. Comparison of the major cell populations among osteoarthritis, Kashin-Beck disease and healthy chondrocytes by single-cell RNA-seq analysis. Cell Death Dis. 2021 May 27;12(6):551.
3. Wang X, Wu Y, Liu Y, Chen F, Chen S, Zhang F, Li S, Wang C, Gong Y, Huang R, Hu M, Ning Y, Zhao H, Guo X. Altered gut microbiome profile in patients with knee osteoarthritis. Front Microbiol. 2023 May 12;14:1153424.
4. Wu Y, Gong Y, Liu Y, Chen F, Chen S, Zhang F, Wang C, Li S, Hu M, Huang R, Guo X, Wang X*, Ning Y, Yang L. Comparative Analysis of Differentially Expressed Genes in Chondrocytes from Rats Exposed to Low Selenium and T-2 Toxin. Biol Trace Elem Res. 2023 Jun 16. doi: 10.1007/s12011-023-03725-w. Online ahead of print.
5. Ning Y, Hu M, Chen S, Zhang F, Yang X, Zhang Q, Gong Y, Huang R, Liu Y, Chen F, Pei L, Guo X, Kang L, Wang X, Zhang Y, Wang X*. Investigation of selenium nutritional status and dietary pattern among children in Kashin-Beck disease endemic areas in Shaanxi Province, China using duplicate portion sampling method. Environ Int. 2022 Jun;164:107255.
6. Ning Y, Hu M, Gong Y, Huang R, Xu K, Chen S, Zhang F, Liu Y, Chen F, Chang Y, Zhao G, Li C, Zhou R, Lammi MJ, Guo X, Wang X*. Comparative analysis of the gut microbiota composition between knee osteoarthritis and Kashin-Beck disease in Northwest China. Arthritis Res Ther. 2022 May 30;24(1):129.
7. Ning Y, Chen S, Zhang F, Liu Y, Chen F, Li S, Wang C, Wu Y, Gong Y, Hu M, Huang R, Guo X, Yang L, Wang X*. The alteration of urinary metabolomics profiles in Kashin-Beck disease in a three consecutive year study. Mol Omics. 2023 Feb 20;19(2):137-149.
8. Gong Y, Wu Y, Liu Y, Chen S, Zhang F, Chen F, Wang C, Li S, Hu M, Huang R, Xu K, Wang X*, Yang L, Ning Y, Li C, Zhou R, Guo X. Detection of selenoprotein transcriptome in chondrocytes of patients with Kashin-Beck disease. Front Cell Dev Biol. 2023 Feb 17;11:1083904.
9. Ning Y, Hu M, Diao J, Gong Y, Huang R, Chen S, Zhang F, Liu Y, Chen F, Zhang P, Zhao G, Chang Y, Xu K, Zhou R, Li C, Zhang F, Lammi M, Wang X*, Guo X. Genetic Variants and Protein Alterations of Selenium- and T-2 Toxin-Responsive Genes Are Associated With Chondrocytic Damage in Endemic Osteoarthropathy. Front Genet. 2022 Jan 11;12:773534.
10. Wang X, Ning Y, Zhang P, Li C, Zhou R, Guo X. Hair multi-bioelement profile of Kashin-Beck disease in the endemic regions of China. J Trace Elem Med Biol. 2019 Jul;54:79-97.
11. Wang X, Ning Y, Zhang P, Yang L, Li C, Zhou R, Guo X. Biological Analysis of Gene Expression and Clinical Variables Suggest FZD1 as a Novel Biomarker for Patients with Kashin-Beck Disease, an Endemic Osteoarthritis in China. Dis Markers. 2019 Jan 3;2019:3736198.
12. Wang X, Ning Y, Liu A, Qi X, Liu M, Zhang P, Guo X. The systematic review and meta-analysis of X-ray detective rate of Kashin-Beck disease from 1992 to 2016. BMC Musculoskelet Disord. 2019 Feb 14;20(1):78.
13. Wang X, Zhang P, Ning Y, Yang L, Yu F, Guo X. Serum and Hair Zinc Levels in Patients with Endemic Osteochondropathy in China: A Meta-analysis. Biol Trace Elem Res. 2018 Feb;181(2):227-233.
14.Wang X, Ning Y, Zhou B, Yang L, Wang Y, Guo X. Integrated bioinformatics analysis of the osteoarthritis‑associated microRNA expression signature. Mol Med Rep. 2018 Jan;17(1):1833-1838.
15. Wang X, Ning Y, Yang L, Yu F, Guo X. Zinc: The Other Suspected Environmental Factor in Kashin-Beck Disease in Addition to Selenium. Biol Trace Elem Res. 2017 Oct;179(2):178-184.
16. Wang X, Ning Y, Zhang P, Yang L, Wang Y, Guo X. Chondrocytes damage induced by T-2 toxin via Wnt/β-catenin signaling pathway is involved in the pathogenesis of an endemic osteochondropathy, Kashin-Beck disease. Exp Cell Res. 2017 Dec 1;361(1):141-148.
17. Wang X, Ning Y, Yang L, Liu H, Wu C, Wang S, Guo X. Diagnostic value of circulating microRNAs for osteosarcoma in Asian populations: a meta-analysis. Clin Exp Med. 2017 May;17(2):175-183.
18. Wang X, Ning Y, Tan W, Yu H, Li Z, Guo X. Population-based comparative analysis of differentially expressed genes between Kashin-Beck disease grades I and II. Scand J Rheumatol. 2016;45(3):230-5.
19. Wang X, Ning Y, Zhang F, Yu F, Tan W, Lei Y, Wu C, Zheng J, Wang S, Yu H, Li Z, Lammi MJ, Guo X. Gene expression signature in endemic osteoarthritis by microarray analysis. Int J Mol Sci. 2015 May 19;16(5):11465-81.
20. Wang X, Ning Y, Guo X. Integrative meta-analysis of differentially expressed genes in osteoarthritis using microarray technology. Mol Med Rep. 2015 Sep;12(3):3439-3445.
21. Wang X, Wang S, He S, Zhang F, Tan W, Lei Y, Yu H, Li Z, Ning Y, Xiang Y, Guo X. Comparing gene expression profiles of Kashin-Beck and Keshan diseases occurring within the same endemic areas of China. Sci China Life Sci. 2013 Sep;56(9):797-803.
