Jian Sun, Associate Professor of Endemic Diseases Institute, Xi’an Jiaotong University Health Science Centre.
The member of the Expert Committee for clinical category test questions for the National Physician Qualification Examination.
Research areas:
1. Trace elements regulate osteochondral homeostasis and damage.
2. Cellular signaling and epigenetic regulation osteochondral homeostasis.
Educational background:
Sep, 2006 ~ Sep, 2011 Ph.D. in Basic Medicine (Immunology), from Xian Jiaotong University, Xian, China. Supervisor: Professor Shemin Lu
Sep, 1999 ~ Jul, 2002 Master Degree of Biochemistry and Molecular Biology from Xian Jiaotong University, Xian, China. Supervisor: Professor Junling Cao
Sep, 1993 ~ Jul, 1997 Bachelor degree of Biochemistry from Northwest University, Xian, China
Working Experience:
May, 2020 ~ present Associate Professor of Endemic Diseases Institute, School of Public Health, Xi’an Jiaotong University Health Science Center.
Nov, 2013 ~ May, 2020 Associate Professor of Department of Biochemistry and Molecular Biology, Xi’an Jiaotong University Health Science Centre.
Oct, 2011 ~ Oct, 2013 Post-doc of Department of Biochemistry and Molecular Biology, Xi’an Jiaotong University Health Science Centre.
Jul, 2002 ~ Sep, 2011 Lecture of Department of Biochemistry and Molecular Biology, Xi’an Jiaotong University Health Science Centre.
Jul, 1997 ~ Jun, 2002 Assistant Lecture of Department of Biochemistry and Molecular Biology, Xi’an Medicine University.
Publications
As the first author or the correspondent author:
Mengyao Sun, Safdar Hussin, Yuxiao Hu, Jidong Yan, Zixin Min, Xi Lan, Yuanxu Guo, Yitong Zhao, Dongxian Guo, Huang Huang, Meng Feng, Yan Han, Fujun Zhang, Wenhua Zhu, Liesu Meng, Dongmin Li, Jian Sun* and Shemin Lu*. Maintenance of SOX9 stability and ECM homeostasis by selenium-sensitive PRMT5 in cartilage. Osteoarthritis and Cartilage. 2019 Jun;27(6):932-944. doi: 10.1016/j.joca.2019.02.797.
Jian Sun#, Zixin Min#, Wenxiang Zhao#, Safdar Hussain, YitongZhao, Dongxian Guo, Fujun Zhang, Yuanxu Guo, Mengyao Sun, Ying Yuan, Huang Huang, Yan Han, Nannan Zhong, Peng Xu*, Shemin Lu*. T-2 toxin exposure decreases SECISBP2 mediated selenoproteins expression and induces lesions in the epiphyseal plate of DA rats, exacerbated by selenium deficiency. Cartliage. 2018 Dec 29:1947603518809406. doi: 10.1177/1947603518809406.
Safdar Hussain, Mengyao Sun, Yuanxu Guo, Nosheen Mushtaq, Yitong Zhao, Ying Yuan, Nazim Hussain, Nazim Hussain, Abubakar Suleiman, Muhammad Sadiq, Fujun Zhang, Yan Han, Jian Sun*, and Shemin Lu*. SFMBT2 positively regulates SOX9 and chondrocytes proliferation. International Journal of Molecular Medicine. 2018 Dec;42(6):3503-3512. doi: 10.3892/ijmm.2018.3894.
Zixin Min#, Yuanxu Guo#, Mengyao Sun, Safdar Hussain, YitongZhao, Dongxian Guo, Ying Yuan, Huang Huang, Lisong Heng, Peng Xu, Fujun Zhang, Qilan Ning, Yan Han, Nannan Zhong, Jian Sun*, Shemin Lu*. Selenium-sensitive miRNA-181a-5p targeting SECISBP2 regulates selenoprotein expression in cartilage. Journal of Cellular and Molecular Medicine. 2018 Nov; Dec;22(12):5888-5898. doi: 10.1111/jcmm.13858.
Safdar Hussain, Mengyao Sun, Zixin Min, Yuanxu Guo, Jing Xu, Nosheen Mushtaq, Lisong Heng, Huang Huang, Yitong Zhao, Ying Yuan, Nazim Hussain, Abu Bakkar, Fujun Zhang, Yan Han, Peng Xu, Jian Sun*, and Shemin Lu*. Down-regulated in OA cartilage, SFMBT2 contributes to NF-kB mediated ECM degradation. Journal of Cellular and Molecular Medicine. 2018 Nov; 22(11): 5753-5758. doi: 10.1111/jcmm.13826.
Yuanxu Guo, Zixin Min, Congshan Jiang, Wei Wang, Jidong Yan, Peng Xu, Ke Xu, Jing Xu, Mengyao Sun, Yitong Zhao, Safdar Hussain, Rui Zhang, Quancheng Wang5, Yan Han, Fujun Zhang, Wenhua Zhu, Dongmin Li, Liesu Meng, Jian Sun* and Shemin Lu*. Downregulatation of HS6ST2 by miR-23b-3p enhances matrix degradation through p38 MAPK pathway in osteoarthritis. Cell Death & Disease. 2018 Jun 13;9(6):699. doi: 10.1038/s41419-018-0729-0.
Zixin Min, Wenxiang Zhao, Nannan Zhong, Yuanxu Guo, Qingzhu Sun, Quancheng Wang, Rui Zhang, Jidong Yan, Lifang Tian, Fujun Zhang, Yan Han, Qilan Ning, Liesu Meng, Jian Sun*, Shemin Lu*. Abnormality of epiphyseal plate induced by selenium deficiency diet in two generation DA rats. APMIS. 2015 Aug;123(8):697-705. doi: 10.1111/apm.12404.
Nannan Zhong#, Jian Sun#, Zixin Min, Wenxiang Zhao, Rui Zhang, WeiWang, Juan Tian, Lifang Tian, Jie Ma, Dongmin Li, Yan Han, Shemin Lu*. MicroRNA-337 influences chondrogenesis through regulating TGFBR2 expression. Osteoarthritis and Cartilage. 2012 Jun;20(6):593-602. doi: 10.1016/j.joca.2012.03.002. WOS:000304733900018.
Jian Sun, Qingzhu Sun, Shemin Lu*. From selenoprotein to endochondral ossification: A novel mechanism with microRNAs potential in bone related diseases? Medical Hypotheses. 2011 Nov; 77(11) 807–811. doi: 10.1016/j.mehy.2011.07.042.
Jian Sun#, Nannan Zhong#, Qibin Li, Zixin Min, Wenxiang Zhao, Qingzhu Sun, Lifang Tian, Hang Yu, Qian Shi, Fujun Zhang, Shemin Lu*. MicroRNA of rats articular cartilage at different developmental stages identified by Solexa sequencing. Osteoarthritis and Cartilage. 2011 Oct;19(10):1237-45. doi: 10.1016/j.joca.2011.07.002.
Jie Ma#, Jian Sun#, Huan Zhang, Rui Zhang, Wan-Hu Kang, Cheng-Ge Gao, Hai-Sheng Liu, Xue-Hong Ma, Zi-Xin Min, Wen-Xiang Zhao, Qi-Lan Ning, Shu-Hong Wang, Yin-Cang Zhang, Ting-Wei Guo, She-Min Lu*. Evidence for transmission disequilibrium at the DAOA gene locus in a schizophrenia family sample. Neuroscience Letters. 2009 Sep 22;462(2):105-8. doi: 10.1016/j.neulet.2009.06.070.
Sun Jian, Cao Jun-ling*, Yang Xu-dong, Meng Lie-su. Disturbance of nivalenol on expression of adhesion molecule CD44 on surface of cultured chondrocytes (in English). Chinese Journal of Clinical Rehabilitation. 2006; 10(1):177-180
As the co-author:
[1] Yongsong Cai, Congshan Jiang, Jialin Zhu, Ke Xu, Xiaoyu Ren, Lin Xu, Peijing Hu, Bo Wang, Qiling Yuan, Yuanxu Guo, Jian Sun, Peng Xu, Yusheng Qiu. miR-449a inhibits cell proliferation, migration, and inflammation by regulating high-mobility group box protein 1 and forms a mutual inhibition loop with Yin Yang 1 in rheumatoid arthritis fibroblast-like synoviocytes. Arthritis Res Ther. 2019 Jun 3; 21(1):134.
[2] Jialin Zhu, Yongsong Cai, Ke Xu, Xiaoyu Ren, Jian Sun, Shemin Lu, Jinghong Chen, Peng Xu. Beclin1 overexpression suppresses tumor cell proliferation and survival via an autophagy-dependent pathway in human synovial sarcoma cells. Oncology Reports. 2018 Oct; 40(4):1927-1936.
[3] Ying He, Wen Yao , Meng Zhang, Ying Zhang, Dan Zhang, Zhuocheng Jiang, Tianyou Ma, Jian Sun, Mingming Shao, Jinghong Chen. Changes in osteogenic gene expression in hypertrophic chondrocytes induced by SIN-1. Exp Ther Med. 2018 Aug; 16(2): 609-618. doi: 10.3892/etm.2018.6261.
[4] Le Yang, Yongsong Cai, Ke Xu, Jialin Zhu, Yuanbo Li, Xiaoqing Wu, Jian Sun, Shemin Lu, Peng Xu. Sodium selenite induces apoptosis and inhibits autophagy in human synovial sarcoma cell line SW982 in vitro. Molecular Medicine Reports. 2018, 17:(5) pp.6560-6568.
[5] Hussain Nazim, Zhu Wenhua, Jiang Congshan, Xu Jing, Wu Xiaoying, Geng Manman, Hussain Safdar, Cai Yongsong, Xu Ke, Xu Peng, Han Yan, Sun Jian, Meng Liesu, Lu Shemin. Downregulation of miR-10a-5p in synoviocytes contributes to TBX5 controlled joint inflammation. Journal of Cellular and Molecular Medicine. 2018 Jan;22(1):241-250. doi: 10.1111/jcmm.13312
[6] Yuanbo Li, Peng Xu, Ke Xu, Yong-Song Cai, Mengyao Sun, Le Yang, Jian Sun, Shemin Lu. Methotrexate affects HMGB1 expression in rheumatoid arthritis, and the down-regulation of HMGB1 prevents rheumatoid arthritis progression. Molecular and Cellular Biochemistry. Molecular and Cellular Biochemistry. 2016 Sep;420(1-2):161-70. doi: 10.1007/s11010-016-2783-1.
[7] Li Liu#, Qingzhu Sun#, Rujuan Bao, Michael Roth, Bo Zhong, Xi Lan, Jia Tian, Qirui He, Dongmin Li, Jian Sun, Xudong Yang*, Shemin Lu*. Specific regulation of PRMT1 expression by PIAS1 and RKIP in epithelia and fibroblasts relying on acute or chronic lung inflammation. Scientific Reports. 2016 Feb 25;6:21810. doi: 10.1038/srep21810.
[8] Xi Lan, Jidong Yan, Juan Ren, Bo Zhong, Jing Li, Yue Li, Li Liu, Jing Yi, Qingzhu Sun, Xudong Yang, Jian Sun, Liesu Meng, Wenhua Zhu, Rikard Holmdahl, Dongmin Li*, Shemin Lu*. A Novel Long Non-coding RNA Lnc-HC Binds hnRNPA2B1 to Regulate Expression of Cyp7a1 and ABCA1 in Hepatocytic Cholesterol Metabolism. Hepatology. 2016 Jul;64(1):58-72. doi: 10.1002/hep.28391.
[9] Qingzhu Sun#, Li Liu#, Jia Tian, Qirui He, Xi Lan, Congshan Jiang, Bo Zhong, Jian Sun, Xudong Yang*, Shemin Lu*. PRMT1 upregulated by epithelial proinflammatory cytokines participates in COX2 expression in fibroblasts and chronic antigen-induced pulmonary inflammation. Journal of Immunology. 2015 May 29. pii: 1402465.
[10] Jing Xu, Congshan Jiang, Wenhua Zhu, Bo Wang, Jidong Yan, Zixin Ming, Manman Geng, Yan Han, Qilan Ning, Fujun Zhang, Jian Sun, Liesu Meng*, Shemin Lu*. NOD2 is involved in the aberrant catabolism induced by T-2 toxin in chondrocytes. Osteoarthritis and Cartilage. 2015 Apr 24. pii: S1063-4584(15)01136-X. doi: 10.1016/j.joca.2015.04.016.
[11] Wenhua Zhu, Congshan Jiang, Jing Xu, Manman Geng, Xiaoying Wu, Jian Sun, Jie Ma, Rikard Holmdahl, Liesu Meng*, Shemin Lu*. Pristane primed rat T cells enhance TLR3 expression of fibroblast like synoviocytes via a TNF-alpha initiated p38 MAPK pathway. Clinical immunology. 2014 Dec 19. pii: S1521-6616(14)00272-1. doi: 10.1016/j.clim.2014.11.008.
[12] Congshan Jiang, Wenhua Zhu, Jing Xu, Bo Wang, Weikun Hou, Rui Zhang, Nannan Zhong, Qilan Ning, Yan Han, Hongchuan Yu, Jian Sun, Liesu Meng and Shemin Lu*. MicroRNA-26a Negatively Regulates Toll-like Receptor 3 Expression in Rat Macrophages. Arthritis Research & Therapy. Jan 14;16(1):R9. doi: 10.1186/ar4435. 2014.
[13] Juan Tian, Jidong Yan, Wei Wang, Nannan Zhong, Lifang Tian, Jian Sun, Zixin Min, Jie Ma, Shemin Lu*. T-2 toxin enhances catabolism of hypertrophic chondrocytes through ROS-NF-κB-HIF-2α pathway. Toxicology in vitro. 2012 Oct;26(7):1106-13. doi: 10.1016/j.tiv.2012.07.002.
[14] Qingzhu Sun, Xudong Yang, Bo Zhong, Fangfang Jiao, Chenyan Li, Dongmin Li, Xi Lan, Jian Sun, Shemin Lu*. Upregulated Protein Arginine Methyltransferase 1 by IL-4 Increases Eotaxin-1 Expression in Airway Epithelial Cells and Participates in Antigen-Induced Pulmonary Inflammation in Rats. Journal of Immunology. 2012 Apr 1;188(7):3506-12. 2011 Dec;50(12):2176-86. doi: 10.4049/jimmunol.1102635.
[15] Wang Wei, Zhong Bo; Sun Jian, Cao Junling, Tian Juan, Zhong Nannan, Zhao Wenxiang, Tian Lifang, Xu Peng, Guo Dawei, Ju Xichi, Ma Wei, Li Meng, Hou Weikun, Lu Shemin*. Downregulated HS6ST2 in osteoarthritis and Kashin Beck disease inhibits cell viability and influences expression of the genes relevant to aggrecan metabolism of human chondroncytes. Rheumatology. 2011 Dec;50(12):2176-86. doi: 10.1093/rheumatology/ker230.
[16] Lifang Tian, Wei Wang, Weikun Hou, Juan Tian, Nannan Zhong, Jian Sun, Dawei Guo, Jianfeng Yao, Peng Xu, Peihe Su, Lan He, Shemin Lu*. Autoimmune and inflammatory responses in Kashin-Beck Disease in comparison with rheumatoid arthritis and osteoarthritis. Human Immunology. 2011 Oct;72(10):812-6. doi: 10.1016/j.humimm.2011.05.021.
[17] Junling Cao, Siyuan Li, Zhongli Shi, Yan Yue, Jian Sun, Jinghong Chen, Qiang Fu, C.E.Hughes and B.Caterson*. Articular cartilage metabolism in patients with Kashine-Beck Disease an endemic osteoarthropathy in China. Osteoarthritis and Cartilage. 2008 Jun;16(6):680-8. doi:10.1016/j.joca.2007.09.002.
Contact：
Email: sunjian1@xjtu.edu.cn
Address：No.76 Yanta West Road, Xi'an, Shaanxi Province, China (Xi'an Jiaotong University Health science Center)
Postcode：710061
