Wen yan
Research area (Research direction)
The study of environment-gene interaction in the development of Kashin-Beck disease, molecular epidemiology
Educational experience:
2011-2016, School of Public Health, Xi’an Jiaotong University Health Science Center, Occupational and Environmental Health, Doctor
2016 till now，Institution of Endemic Diseases, School of Public Health, Xi’an Jiaotong University Health Science Center, Lecturer
Achievements, patents and papers
[1] Yan Wen, Feng Zhang, Xiancang Ma, Qianrui Fan, Wenyu Wang, Jiawen Xu, Feng Zhu, Jingcan Hao, Awen He, Li Liu, Xiao Liang, Yanan Du, Ping Li, Cuiyan Wu, Sen Wang, Xi Wang, Yujie Ning, Xiong Guo,. eQTLs weighted genetic correlation analysis detected brain region differences in genetic correlations for complex psychiatric disorders. Schizophrenia Bulletin. 2018.
[2] Yan Wen, Ping Li, Jingcan Hao, Chen Duan, Jing Han, Awen He, Yanan Du, Li Liu, Xiao Liang, Feng Zhang, Xiong Guo 1Integrating genome-wide DNA methylation and mRNA expression profiles identified different molecular features between Kashin-Beck disease and primary osteoarthritis. Arthritis Research and Therapy. 2018 Mar 7;20(1):41.
[3] Yan Wen, Wenyu Wang, Xiong Guo, Feng Zhang. PAPA: a flexible tool for identifying pleiotropic pathways using genome-wide association study summaries. Bioinformatics. 2016 Mar 15;32(6):946-8.
[4] Yan Wen, Xiong Guo, Jingcan Hao, Xiao Xiao, Wenyu Wang, Cuiyan Wu, Shuang Wang, Tielin Yang, Hui Shen, Xiangding Chen, Lijun Tan, Qing Tian, Hong-Wen Deng, Feng Zhang. Integrative analysis of genome-wide association studies and gene expression profiles identified candidate genes for osteoporosis in Kashin-Beck disease patients. Osteoporosis International. 2016 Mar;27(3):1041-6.
[5] Yan Wen, Jingcan Hao, Xiao Xiao, Xiong Guo, Wenyu Wang, Tielin Yang, Hui Shen, Qing Tian, Lijun Tan, Hong-Wen Deng. Feng Zhang. Evaluation of the relationship and genetic overlap between Kashin-Beck disease and body mass index. Scandinavian Journal of Rheumatology. 2016 Apr 7:1-6.
[6] Yan Wen, Jingcan Hao, Xiao Xiao, Wenyu Wang, Xiong Guo, Weimin Lin, Tielin Yang, Xiaogang Liu, Hui Shen, Lijun Tan, Xiangding Chen, Qing Tian, Hong-Wen Deng, Feng Zhang. PPARGC1B gene is associated with Kashin-Beck disease in Han Chinese. Functional & Integrative Genomics. 2016 Apr 23; 16(4):459-463.
[7] Yan Wen, Jingcan Hao, Xiong Guo, Xiao Xiao, Cuiyan Wu, Sen Wang, Tielin Yang, Hui Shen, Xiangding Chen, Lijun Tan, Qing Tian, Hong-Wen Deng, Feng Zhang. SWGDT: A sliding window-based genotype dependence testing tool for genome-wide susceptibility gene scan. Journal of Biomedical Informatics. 2015 Oct; 57:38–418.
[8] Yan Wen, Feng Zhang, Chunyan Li, Shulan He, Wuhong Tan, Yanxia Lei, Qiang Zhang, Hanjie Yu, Jingjing Zheng, Xiong Guo. Gene expression analysis suggests bone development-related genes GDF5 and DIO2 are involved in the development of Kashin-Beck disease in children rather than adults. PLoS One. 2014 Jul 29;9(7):e103618.
[9] Wu Cuiyan, Wen Yan, Guo Xiong, Yang Tielin, Shen Hui, Chen Xiangding Tian Qing, Tan Lijun, Deng Hong-Wen, Zhang Feng. Genetic association, mRNA and protein expression analysis identify ATG4C as a susceptibility gene for Kashin-Beck disease. Osteoarthritis Cartilage. 2017, 25(2):281-286.
[10] Du Yanan, Wen Yan, Guo X1, Hao J1, Wang W1, He A1, Fan Q1, Li P1, Liu L1, Liang X1, Zhang F2. A Genome-wide Expression Association Analysis Identifies Genes and Pathways Associated with Amyotrophic Lateral Sclerosis.[J]. Cellular & Molecular Neurobiology, 2017:1-5.
[11]Feng Zhang, Yan Wen, Xiong Guo, Tielin Yang, Hui Shen, Xiangding Chen, Lijun Tan, Qing Tian, Hong-Wen Deng. Trans-omics pathway analysis suggests that eQTLs contribute to chondrocyte apoptosis of Kashin-Beck disease through regulating apoptosis pathway expression. Gene. 2014 Dec 15;553(2):166-9.
[12] Feng Zhang, Yan Wen, Xiong Guo, Yingang Zhang, Xi Wang, Tielin Yang, Hui Shen, Xiangding Chen, Qing Tian, Hong-Wen Deng. Genome-wide association study identifies ITPR2 as a susceptibility gene for Kashin-Beck disease in Han Chinese. Arthritis & Rheumatology. 2015 Jan;67(1):176-81.
[13] Feng Zhang, Yan Wen, Xiong Guo. CRISPR/Cas9 for genome editing: progress, implications and challenges. Human Molecular Genetics. 2014 Sep 15;23(R1):R40-6.
Contact
Email：wenyan@xjtu.edu.cn
