Ning Yujie
Assistant professor,
School of Public Health
Xi’an Jiaotong University Health Science Center
No.76 Yanta West Road, Xi’an, China
E-mail: ning461871077@xjtu.edu.cn
Educational experience:
2005. 9-2010. 7：Shaanxi University of Chinese Medicine
2010. 9-2016.9：Xi’an Jiaotong University Health Science Center
2014. 12-2015.12：The University of Sydney, Australia
Occupational experience:2016. 10-now：Assistant professor, Xi’an Jiaotong University Health Sciences Center
Research Interests:The etiology, pathogenesis, prevention and treatment of Kashin-Beck disease; paediatric nutrition; pathogenesis of environmental and gene related diseases
Research Grants：
1. National Nature Science Foundation of China. Protective Role and Mechanism of Dietary Exosome miR-23b in Repairing Chondrocyte Lesions in Kashin-Beck Disease, 220,000￥, 2019-2021, PI –Ning Yujie
2. China Postdoctoral Science Foundation-General project. The Role of MiR-23b in Cartilage Damage of Kashin-Beck Disease through PKA Signaling Pathway, 50,000￥, 2017-2018, PI –Ning Yujie
3. Shaanxi Natural Science Fund Youth Project. The Role of Exosome in Cartilage Damage of Kashin-Beck Disease through NFkB Signaling Pathway. 30,000￥, 2018-2019, PI- Ning Yujie
Publications：
[1].Yujie Ning, Xi Wang, Pan Zhang, Skalny V. Anatoly, N. Tejo Prakash, Cheng Li, Rong Zhou, Mikko Lammi, Feng Zhang, Xiong Guo*. Imbalance of Dietary Nutrients and Associated Differentially Expressed Genes and Pathways May Play Important Roles in Juvenile Kashin-Beck Disease. Journal of Trace Elements in Medicine and Biology, 2018, Epub ahead of print.
[2].Yujie Ning, Xi Wang, Pan Zhang, Amin Liu, Xin Qi, Meidan Liu, Xiong Guo*. Dietary Exosome‑miR‑23b May be a Novel Therapeutic Measure for Preventing Kashin‑Beck Disease. Experimental and Therapeutic Medicine. 2018; 15(4):3680-3686.
[3].Yujie Ning, Xi Wang, Xiong Guo*, Pan Zhang, Pengfei Qu, Feng Zhang, Sen Wang, Yanxia Lei, Mikko Lammi, Nutrients Other than Selenium Are Important for Promoting Children's Health in Kashin-Beck Disease Areas. Biological Trace Element Research, Epub ahead of print, 2017.
[4].Yujie Ning, Xi Wang, Sen Wang, Xiong Guo*. Comparative Analysis on Signaling Pathways of Peripheral Blood Mononuclear Cells between Kashin-Beck Disease and Osteoarthritis. Experimental and Therapeutic Medicine. 2016;12(6):4077-4084.
[5].Yujie Ning, Xi Wang, Sen Wang, Feng Zhang, Lianhe Zhang, Yanxia Lei, Xiong Guo*. Is It the Appropriate Time to Stop Applying Selenium Enriched Salt in Kashin-Beck Disease Areas in China? Nutrients. 2015; 7:6195-6212.
[6].Yujie Ning, Xi Wang, Lin Ren, Xiong Guo*. The Effects of Dietary Factors on Selenium Nutrition Levels of Children to Prevent Kashin-Beck Disease in High Prevalence Period of Endemic Area: an Analysis of Cohort Study. Biological Trace Element Research. 2013; 153(1-3):58-68.
[7]. Yan Zhao,Yujie Ning (co-first author), Feng Zhang*, Miao Ding, Yan Wen, Liang Shi, Kunpeng Wang, Mengnan Lu, Jingyan Sun, Menglu Wu, Bolun Cheng, Mei Ma, Lu Zhang, Shiqiang Cheng, Hui Shen, Qing Tian, Xiong Guo and Hong-Wen Deng. PCA-based GRS analysis enhances the effectiveness for genetic correlation detection. Briefings in Bioinformatics. 2018, [Epub]
[8]. Yanan Du,Yujie Ning (co-first author), Yan Wen, Li Liu, Xiao Liang, Ping Li, Miao Ding, Yan Zhao, Bolun Cheng, Mei Ma, Lu Zhang, Shiqiang Cheng, Wenxing Yu, Shouye Hu, Xiong Guo, Feng Zhang*. A genome-wide pathway enrichment analysis identifies brain region related biological pathways associated with intelligence. Psychiatry Research. 2018; 268:238-242.
[9]. Awen He,Yujie Ning (co-first author), Yan Wen, Yongsong Cai, Ke Xu, Yuanzhen Cai, Jing Han, Li Liu, Yanan Du, Xiao Liang, Ping Li, Qianrui Fan, Jingcan Hao, Xi Wang, Xiong Guo, Feng Zhang*. Use of Integrative Epigenetic and mRNA Expression Analyses to Identify Significantly Changed Genes and Functional Pathways in Osteoarthritic Cartilage. Bone Joint Res. 2018; 7(5): 343-350.
[10]. Xi Wang,Yujie Ning (co-first author),Lei Yang, Fangfang Yu, Xiong Guo*. Zinc: the Other Suspected Environmental Factor in Kashin-Beck Disease in Addition to Selenium. Biological Trace Element Research, 2017; 179(2):178-184.
[11]. Xi Wang,Yujie Ning (co-first author), Pan Zhang, Lei Yang, Yingting Wang, Xiong Guo*, Chondrocytes Damage Induced by T-2 Toxin via Wnt/β-Catenin Signaling Pathway is Involved in the Pathogenesis of an Endemic Osteochondropathy, Kashin-Beck Disease, Experimental Cell Research, 2017; 361(1):141-148.
[12]. Xi Wang,Yujie Ning (co-first author), Bing Zhou, Lei Yang, Yingting Wang, Xiong Guo*, Integrated Bioinformatics Analysis of the Osteoarthritis‑Associated microRNA Expression Signature, Molecular Medicine Reports, 2017; 17(1):1833-1838.
[13]. Xi Wang,Yujie Ning (co-first author), Lei Yang, Huan Liu, Cuiyan Wu, Sen Wang, Xiong Guo*, Diagnostic Value of Circulating microRNAs for Osteosarcoma in Asian Populations: A Meta-analysis, Clinical and Experimental Medicine, 2017;17(2):175-183.
[14]. Xi Wang,Yujie Ning (co-first author), Wuhong Tan, Hanjie Yu, Zheng Li, Xiong Guo*. Population-based Comparative Analysis of Differentially Expressed Genes between Kashin-Beck Disease GradeⅠand Ⅱ. Scandinavian Journal of Rheumatology. 2016;45(3):230-235.
[15]. Xi Wang,Yujie Ning (co-first author), Feng Zhang, Fangfang Yu, Wuhong Tan, Yanxia Lei, Cuiyan Wu, Jingjing Zheng, Sen Wang, Hanjie Yu, Zheng Li, Mikko J. Lammi, Xiong Guo*. Gene Expression Signature in Endemic Osteoarthritis by Microarray Analysis. International Journal of Molecular Sciences. 2015; 16: 11465-11481.
[16]. Xi Wang,Yujie Ning (co-first author), Xiong Guo*. Integrative Meta-analysis of Differentially Expressed Genes in Osteoarthritis using Microarray Technology. Molecular Medicine Reports. 2015; 12(3):3439-45.
[17]. Xi Wang, Pan Zhang,Yujie Ning, Lei Yang, Fangfang Yu, Xiong Guo*. Serum and Hair Zinc Levels in Patients with Endemic Osteochondropathy in China: A Meta-analysis, Biological Trace Element Research, 2018; 181(2):227-233.
[18]. Xi Wang, Shuang Wang, Shulan He, Feng Zhang, Wuhong Tan, Yanxia Lei, Hanjie Yu, Zheng Li,Yujie Ning, Youzhang Xiang, Xiong Guo*. Comparing Gene Expression Profiles of Kashin-Beck and Keshan Disease Occurring within the Same Endemic Areas of China. Science China Life Sciences. 2013; 56(9):797-803.
[19]. Lei Yang, Jianping Zhang, Guanghui Zhao, Cuiyan Wu,Yujie Ning, Xi Wang*, Mikko J. Lammi, Xiong Guo*. Gene Expression Profiles and Molecular Mechanism of Cultured Human Chondrocytes’ Exposure to T-2 Toxin and Deoxynivalenol. Toxicon, 2017; 140:38-44.
[20]. Qianrui Fan, Wenyu Wang, Jingcan Hao, Awen He, Yan Wen, Xiong Guo, Cuiyan Wu,Yujie Ning, Xi Wang, Sen Wang, Feng Zhang*. Integrating Genome-Wide Association Study and Expression Quantitative Trait Loci Data Identifies Multiple Genes and Gene Set Associated with Neuroticism. Progress in Neuropsychopharmacology & Biological Psychiatry, 2017, 78:1-17.
[21]. Qianrui Fan, Feng Zhang*, Wenyu Wang, Xu J, Jingcan Hao, Awen He, Yan Wen, Ping Li, Xiao Liang, Yanan Du, Li Liu, Cuiyan Wu, Sen Wang, Xi Wang,Yujie Ning, Xiong Guo. GWAS summary-based pathway analysis correcting for the genetic confounding impact of environmental exposures. Brief. Bioinformatics, 2017.
[22]. Wenyu Wang, Yan Yu, Jingcan Hao, Yan Wen, Jing Han, Weikun Hou, Ruiyu Liu, Bo Zhao, Awen He, Ping Li, Qianrui Fan, Cuiyan Wu, Sen Wang, Xi Wang,Yujie Ning, Xiong Guo , Feng Zhang*. Genome-Wide DNA Methylation Profiling of Articular Cartilage Reveals Significant Epigenetic Alterations in Kashin-Beck Disease and Osteoarthritis. Osteoarthritis and Cartilage, 2017, 25(12): 2127-2133.
Academicconference experience
[1]. Se Metabolism System Disorder in Kashin-Beck Disease. 2018 XJTU-SNU joint workshop on Kashin-Beck disease. March 29-April 2, 2018 Xi’an, China. (Invited speaker)
[2]. Investigation on Dietary Nutrients and Screening of Differentially Expressed Genes and Pathways Related to Nutrients in Children from Endemic Areas of Kashin-Beck Disease. The ninth national conference on endemic diseases of Chinese medical association. November 20-23, 2016 Nanning, China. (Invited speaker)
[3]. The Effects of Dietary Factors on Selenium Nutrition Levels of Children to Prevent Kashin-Beck Disease in High Prevalence Period of Endemic Area: an Analysis of Cohort Study. The International Selenium Seminar 2013. October, 17-21, 2013 Xi’an, China. (Invited speaker)
